Thinking about today:

Oral? Inhale?Sublingual? Topical? Recreational?

What is the best way to Cannabis CBD?

Food? Vaporization? Drops? External use? Drugs?

Today's topic shared by DrHemp:

From the point of view of bioavailability, Vaporized CBD is indeed the worthiest of consideration.

According to the investigation of authoritative organizations, from CBD is indeed the most promising product embodiment at present.

Have you ever wondered why many vitamin tablets, medicines and health products are taken with meals? Takeing these drugs orally according to the doctor's advice, because the chemicals and ingredients in them are more easily absorbed by the body when taken with meals. That is, the diet increases the bioavailability of the supplements or drugs being taken.

So what is the bioavailability of CBD? In short, the exact percentage of CBD absorbed by blood.

CBD is the abbreviation of Cannabidiol, which is a naturally occurring compound in cannabis plants and has no psychoactive activity. Since decriminalization and legalization have been more widely implemented in the United States, CBD has attracted more and more attention due to its potential multiple therapeutic properties and good safety and tolerance. People widely use CBD to treat anxiety, pain, sleep disorders, skin problems, etc., but how to take CBD has caused an important problem in the bioavailability of CBD.

The bioavailability of CBD is important, because the dose a person takes depends on the administration route and the specific product he uses. When CBD is absorbed, only a small part of the required ingredients or compounds are absorbed and provided to the body, and the main factors that determine the bioavailability of CBD are the types of CBD products consumed and consumption patterns.

Today's consumers can simply find CBD products in various forms, including tincture, balm, analgesic spray, cream, steam, capsules, etc. Each form of CBD products has its own benefits, and product manufacturers are seeking ways to improve bioavailability so that consumers can get the greatest benefits. Today, doctors share around the most common ways:

01 [Oral] food

Similar to any other medicine taken with meals, CBD food has the same purpose. Consumers can eat CBD in the form of food or swallow it like a capsule. Your body will process CBD—- in your digestive system-it passes through your stomach and then into your liver, where it is metabolized. After metabolism, CBD will be released into your blood. The authoritative data released by WHO is that the bioavailability of CBD at intake is 6%. This means that swallowing about 100mg of CBD will cause about 6mg of CBD to be absorbed in the blood.

In the CBD evaluation report released by the Expert Committee on Drug Dependence in 2017, the World Health Organization clearly pointed out the following important points: "Pharmacokinetics The oral administration of CBD oil-based capsule preparation has been evaluated in human body. The absorption of CBD from gastrointestinal tract may be unstable due to its poor water solubility, and the resulting pharmacokinetic characteristics are variable. Due to the significant first-pass effect, the bioavailability of oral administration is estimated to be 6%. In healthy male volunteers, it was reported that the average SD whole blood levels of CBD were 0.36 (0.64) ng/mL, 1.62 (2.98) ng/mL and 3.4 (6.42)) ng/mL at 1, 2 and 3 hours after taking 600mg CBD orally. It is reported that Vaporized CBD can produce rapid peak plasma concentration within 5-10 minutes, and has higher bioavailability than oral administration. "

02 [Inhale]Vaporization

As recommended by WHO, one of the fastest ways to ingest CBD is Vaporization , which allows compounds to enter your lungs directly. This is where the compound is easily absorbed into the blood. According to the medical research of INNOCAN PHARMA, a well-known medical cannabis company in Israel, the bioavailability of Vaporized CBD is 10% to 60%. This means that Vaporizing about 100mg of CBD will cause about 10-60mg of CBD to be absorbed in the blood.

Well-known cannabis website Leafly reported that the research results of CV Sciences also mentioned that in view of the loss of CBD in the absorption process, the amount of CBD dissolved from blood can be reduced by placing CBD in a more hydrophilic or water-soluble form. However, this can only be achieved by complex chemical methods, such as using cyclodextrin or liposome. A more practical solution is to completely use Vaporization to bypass the first-pass effect of oral administration. During vaporization, CBD enters your lungs and spreads directly into the blood, rather than through the intestines and liver. This completely avoids the first-pass effect, allowing nearly four times of CBD to enter the circulation, and the maximum bioavailability is about 50% to 60%. This means that Vaporizing about 100mg of CBD will cause about 50-60mg of CBD to be absorbed in the blood. Essentially, this means that a smaller amount of CBD can be used to achieve the same beneficial effect.

Not only that,Vaporization will greatly reduce the time required for CBD in the body to become active, because it is not necessary to wait for it to pass through the intestinal tract. By Vaporizing CBD e-liquid or high CBD concentrate, you may feel the effect 30 to 60 minutes faster in advance. This makes Vaporized CBD a very effective drug delivery method.

Of course, the doctor also warmly reminds that if patients in legal countries tend to embrace Vaporized life, please make sure you have done research on the cannabis concentrate you intend to consume. If there is a lack of adequate supervision on the emerging Vaporization equipment and cannabis industry, few companies can produce clear and homogeneous CBD solutions, so the mg content in CBD products is often inconsistent with the amount claimed on the label. Be sure to ask the internal and third-party test results from the selected sources to ensure the quality products.

03 [Sublingual ] drops

Taking CBD oil in the form of sublingual drops is another way of taking it. It needs to leave the oil under the tongue for 60 to 90 seconds, and then the oral mucosa absorbs it. This method of taking CBD can help bypass the liver and digestive system; Instead, the compound is metabolized by enzymes. When you take CBD sublingually, CBD will enter your blood faster, thus having more bioavailability than the edible form, reported at around 13%-19%. The drop form means that about 100 mg of CBD will cause about 13-19mg of CBD to be absorbed in the blood.

04 [Topical] for external use

CBD drug market is huge in the world, especially in the field of beauty and skin care. You can try everything from facial essences and creams to pain-relieving balls and recovery lotions, to body oils, eye essences and sleep masks. However, it is important that the local use of CBD products will not cause CBD to enter the blood. Instead, it will be absorbed by the pores on the skin and transferred down to the dermis (the inner layer of the skin). Compared with CB1 receptors mainly in the central nervous system, there are TRPV1 and CB2 receptors in the peripheral system and skin. The skin permeability to CBD is relatively low, but when you apply a large amount of CBD products for external use on your skin, a small amount of absorption will occur. Some products have proved to be effective in relieving discomfort in some parts, and there is no specific quantitative data yet.

05 [Recreational]

As a leading international and domestic industry leader, HMI Group opposes the legalization of all forms of recreational cannabis. Therefore, DrHempwill not explain it here.

01 Vaporization has the fastest market share increase rate among all product categories!

According to the data released by New Frontier in April 2021, during the period of 2017-2020, the market share of electronic cigarettes in various product categories in the legal cannabis market in the United States increased from 17% to 29%, with the fastest increase rate reaching an astonishing 73%!

02 E-cigarette sales account for 20% of cannabis sales!

Take Colorado, USA as an example. Among the total sales of US$ 7.8 billion from 2014 to 2020, flowers accounted for 43%; E-cigarettes account for 20%; Extract accounts for 17%; Food 14%; Pre-cigarette 4%; 1% for external use; Tincture 1%.

03CBD Vaporization market has broad prospects!

According to the data of Cowen and Company Research Report, the sales of CBD vaporizers in the United States in 2018 was USD 40 million, and the global market space of CBD vaporizers is expected to reach USD 700 million in 2020. Cowen and Company's survey on the distribution of the global CBD vaporizer market shows that the United States, Canada and the United Kingdom have the highest sales, and the United States occupies 45% of the global market.

04E-cigarette is the most common [Vaporization ] equipment in the world today. It is the further support of the [Vaporization ] concept that governments of various countries clear the way for e-cigarette!

"Blue Hole New Consumption" broke out the green light of national policies in the field of e-cigarettes. In fact, apart from Britain's support for e-cigarettes, at least 67 countries around the world have approved e-cigarettes as a less harmful smoking substitute. Watch the latest progress together:

On October 29th, 2021, the British official issued a statement that England became the first country in the world to license electronic cigarettes as medical products. The British government agreed to recommend e-cigarettes as medical smoking cessation products to people who want to quit smoking. By issuing medical e-cigarettes to help reduce the smoking rate, it not only recognized the smoking cessation effect of e-cigarettes from the government level, but also practically implemented it in medical policies to support the use of e-cigarettes. Users who use prescription e-cigarettes will be paid by the government.

On October 25th, according to the report of cross-border e-commerce in the Middle East, Egypt abolished the ban on the sale, import and marketing of e-cigarettes since 2015 last month, in line with the global and Middle East markets, including the United Arab Emirates, Saudi Arabia and Kuwait, which have legalized the marketing and consumption of e-cigarettes.

On October 13th, the US Food and Drug Administration (FDA) authorized e-cigarette products to be legally sold in the US market for the first time, allowing three Vuse e e-cigarette products of RJ Reynolds, a subsidiary of British American Tobacco. So far, the world's first e-cigarette brand that passed American PMTA was born.

On October 11th, New Zealand supported e-cigarettes and endorsed e-cigarettes with national efforts. The fundamental reason why New Zealand advocates electronic cigarettes is to become a smoke-free country in 2025. The government has put forward a series of suggestions and approved the use of e-cigarettes as smoking cessation assistants, and officially affirmed the status of e-cigarettes at the national level. Official website (vapingfacts.health.nz), the New Zealand Health Promotion Agency, has a channel dedicated to the truth about e-cigarettes, and relevant information is jointly provided by the Ministry of Health and the Health Promotion Agency.

The list goes on, so I won't go into details here, ...

But [Oral? Inhale?Sublingual? Topical? Recreational?]In the end, what is the best way to [Cannabis] CBD is still different from person to person, because it is related to each person's actual situation and situation. A thousand readers have a thousand Hamlets. I hope you can read here, have your own opportunities, keep your own free choices and look up to your endless hope.